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3 Interindividual variability and precision response: host factors governing SFN bioavailability and efficacy The journey of SFN from dietary intake to systemic bioactivity is a complex process governed by a series of metabolic conversions and, crucially, modulated by significant inter-individual variation

For context, NICE has issued technology appraisals for semaglutide (Wegovy) for weight management and for tirzepatide (Mounjaro) for weight management, each with specific eligibility criteria based on BMI and the presence of weight-related comorbidities

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